He was awarded the honorary rank of major-general when he finally retired in March 1919. On Saturday evening, 29 April, after being approached by Nurse Elizabeth O'Farrell, he agreed to negotiate with the leaders only if they would surrender unconditionally, and at 2.30 pm that day, accompanied by Nurse O'Farrell, Patrick Pearse surrendered to Lowe.
It was Lowe who ordered the shelling of Liberty Hall by field guns from Trinity College, and who ordered the Sherwood Foresters to continue advancing on Mount Street Bridge with a high cost in casualties. Arriving himself in the early hours of Tuesday morning, Lowe assumed command of British forces in Dublin and set about securing the line between the railway station, Dublin Castle and Trinity College, thus dividing the rebel positions north and south of the river. On being informed of the Rising by phone, he ordered the brigade to Dublin by train. He was commander of the 3rd Reserve Cavalry Brigade, stationed at the Curragh Camp, at the outbreak of the Easter Rising on Monday, 24 April 1916. On the outbreak of the First World War in 1914, Lowe rejoined the army as Inspector of Cavalry, and was appointed as a Brigade Commander with rank of Brigadier-General in 1915. He went on half-pay in March 1907 and retired a year later. He was made a Companion of the Order of the Bath in 1906. In May 1905, he went to the Northern Command as colonel in charge of cavalry records and staff officer for the Imperial Yeomanry.
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He left the 7th Dragoon Guards in March 1903 to become Assistant Quartermaster-General of the II Corps ( Southern Command), being promoted to full colonel. He received both the Queen's and King's South Africa Medal. Lord Kitchener's Final Despatch, 23 June 1902. Lord Kitchener's despatch of 8 August 1901 related how "at midnight on the 30th July Colonel Lowe, 7th Dragoon Guards, successfully surprised a farmhouse, from which he took 11 armed prisoners with rifles, bandoliers and horses." Lowe was twice more Mentioned in Despatches: in Lord Roberts' Recommendations, 2 April 1901 and in From 1900 to 1902, Lowe led the regiment in the Second Boer War, being present at the capture of Pretoria and the Battle of Diamond Hill, and was promoted brevet colonel in November 1900. In 1899, he was promoted to lieutenant-colonel and assumed command of the 7th Dragoon Guards. He was promoted to the rank of captain in 1887 and major in 1892.
Remaining in Burma until 1887, he received the India General Service Medal with two clasps. In 1886, Lowe went to Burma from India, where the 7th Dragoon Guards were stationed, as a special service officer to the Upper Burma Task Force during the guerrilla phase of the Third Anglo-Burmese War. He received the Egypt Medal and the Khedive's Star, a medal presented by Khedive Tawfiq to all officers and men engaged in the campaign. Lowe was involved in the fighting at Kassassin, the Battle of Tel el-Kebir and the march on Cairo.
The following year he saw action in the Egyptian Campaign, where the 7th Dragoon Guards were part of the 1st Cavalry Brigade led by General Sir Baker Russell. He was educated at the Royal Military College, Sandhurst, and commissioned in the 7th Dragoon Guards in 1881. Lowe was born in North-Western Provinces, India, to William Henry Lowe of the Indian Civil Service, and Caroline Charlotte Muir.